Full title: Novel Systems for the Study of Human Disease [electronic resource]: From Basic Research to Applications / Organisation for Economic Co-operation and Development

Author/creator: Organisation for Economic Co operation and Development, Organisation for Economic Co-operation and Development.

Date: 1998..

Call Numbers:

Record Identifier: 74VK3lz5zm0y

Language: English

Formats: ebooks

Contents: 1 online resource (400 p.), , , , EXECUTIVE SUMMARY -- SCIENTIFIC SUMMARY -- OPENING SPEECHES BY HOST COUNTRY -- INTRODUCTION -- Gene targeting: an historical perspective by M. Capecchi, United States -- Somatic gene therapy: from basic science to clinical applications by S. Woo, United States -- CURRENT DEVELOPMENTS IN THE TECHNOLOGY -- -Conditional gene targeting by K. Rajewsky, Germany -- Engineering chromosomes in mice to facilitate the identification of tumour suppressor genes by A. Bradley, United States -- The use of genetic switches for the generation of conditional mutants at the level of cells and animals by H. Bujard, Germany -- -Yeast Artificial Chromosomes as vectors for transgenesis by G. Schütz, Germany -- We need more mutants: plans for a large scale ENU mouse mutagenesis screen by R. Balling, Germany -- INTERNATIONAL FACILITIES AND INFRASTRUCTURE -- The Jackson Laboratory: research to resource by B. Knowles, United States -- The European Mouse Mutant Archive (EMMA) by P. Rigby, United Kingdom -- Supporting transgenic research: repositories and distribution – the CDTA experience by C. Benoist, France -- Rapid and efficient embryo manipulation systems by using cryopreserved mouse embryos, oocytes, and sperm" (Abstract) by M. Katsuki, Japan -- GENERAL DISCUSSION SESSION I: CURRENT DEVELOPMENTS IN THE TECHNOLOGY and INTERNATIONAL FACILITIES AND INFRASTRUCTURES -- FIELDS OF APPLICATION -- Diabetes mellitus – use of transgenic technology to study both the pathophysiological mechanisms of the disease and new therapies by F. Bosch, Spain -- The obese gene: an invaluable chance to explore the mechanisms which regulate body weight by M. Maffei, Italy -- -Cystic Fibrosis – an example of modelling a monogenic disease in the mouse by J. Dorin, United Kingdom -- -Lessons from the Rb mutant mouse by T. Jacks, United States -- The use of transgenic, knock-out and interspecific hybrid mice in studies of cancer predisposition and tumour progression by A. Balmain, United Kingdom -- Oncogene function in normal development and disease by E. Wagner, Austria -- -The construction and use of HIV-1 transgenic mice in AIDS research by M. Martin, United States -- Insights into the ontogeny and activation of T cells in mutant mice by T.W. Mak, Canada -- -Targeted deficiency in the mouse HOXD complex: compound digit defects as a model for the human synpolydactyly syndrome by D. Duboule, Switzerland -- Transgenic mouse models for skeletal diseases (including osteoporosis and osteoarthritis) by E. Vuorio, Finland -- -An experiment-based classification of blood pressure genes by J. Krege, United States -- The use of transgenic mice in the investigation of transmissible Spongiform Encephalopathies by C. Weissmann, Switzerland -- Transgenic animal models of Alzheimer’s disease pathology by B. Cordell, United States -- -Transgenic mouse models for Alzheimer’s disease by F. van Leuven, Belgium -- -Skeletal myogenesis: from determination to therapy G. Cossu, Italy -- Vaccine development and testing: review by M. De Wilde, Belgium -- The transgenic mouse model of poliovirus by P. Minor, United Kingdom -- POLICY ASPECTS AND DISCUSSION -- -Cryopreservation centres: the means to an archive by L. Mobraaten, United States -- Towards a central repository of data on transgenic animals and targeted mutations by A. Anagnostopoulos, United States -- -Drug testing, quality control, and standards by J. Purves, United KingdomGENERAL DISCUSSION SESSION II: FIELDS OF APPLICATION and POLICY ASPECTS AND DISCUSSION -- Transgenic models in drug discovery - an industrial perspective by P. Hardy, France -- -Intellectual property aspects by K. Becker, Switzerland -- PANEL DISCUSSION (SESSION III) AND CONCLUSIONS -- ANNEX: FOLLOW-UP REGARDING INTELLECTUAL PROPERTY -- LIST OF PARTICIPANTS

Publishers: Paris : OECD Publishing, 1998.

Notes: OECD proceedings Novel systems for the study of human disease Bibliographic Level Mode of Issuance: Monograph

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MMS ID: 991023942149202626