Full title: Computational molecular biology : an introduction / Peter Clote, Rolf Backofen.

Author/creator: Backofen, Rolf, Clote, Peter.

Date: 2000..

Call Numbers: N572.80151/1

Record Identifier: 74VvN0NO5mEZ

Language: English

Formats: Books

Contents: ix, 286 p. : ill. ; 25 cm., 1. Molecular Biology -- 1.1. Some Organic Chemistry -- 1.2. Small Molecules -- 1.3. Sugars -- 1.4. Nucleic Acids -- 1.5. Proteins -- 1.6. From DNA to Proteins -- 1.7. Exercises -- 2. Math Primer -- 2.1. Probability -- 2.2. Combinatorial Optimization -- 2.3. Entropy and Applications to Molecular Biology -- 2.4. Exercises -- 2.5. Appendix: Modification of Bezout's Lemma -- 3. Sequence Alignment -- 3.1. Motivating Example -- 3.2. Scoring Matrices -- 3.3. Global Pairwise Sequence Alignment -- 3.4. Multiple Sequence Alignment -- 3.5. Genomic Rearrangements -- 3.6. Locating Cryptogenes and Guide RNA -- 3.7. Expected Length of gRNA in Trypanosomes -- 3.8. Exercises -- 3.9. Appendix: Maximum-Likelihood Estimation for Pair Probabilities -- 4. All About Eve -- 4.1. Introduction -- 4.2. Rate of Evolutionary Change -- 4.3. Clustering Methods -- 4.4. Maximum Likelihood -- 4.5. Quartet Puzzling -- 4.6. Exercises -- 5. Hidden Markov Models -- 5.1. Likelihood and Scoring a Model., 5.2. Re-estimation of Parameters -- 5.3. Applications -- 5.4. Exercises -- 6. Structure Prediction -- 6.1. RNA Secondary Structure -- 6.2. DNA Strand Separation -- 6.3. Amino Acid Pair Potentials -- 6.4. Lattice Models of Proteins -- 6.5. Hart and Istrial's Approximation Algorithm -- 6.6. Constraint-Based Structure Prediction -- 6.7. Protein Threading -- 6.8. Exercises.

Publishers: New York : Wiley, 2000.

Notes: Wiley series in mathematical and computational biology. Includes bibliographical references (p. [269]-279).

Additional physical form availability note: Also available as an electronic book via the World Wide Web to institutions affiliated with netLibrary, Inc.

Permalink: https://collection.sl.nsw.gov.au/record/74VvN0NO5mEZ

DDC: 572.8015118

MMS ID: 991013052129702626