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The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

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The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

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TN_cdi_doaj_primary_oai_doaj_org_article_32ad424ed67248b39855a6f6ea030e5f

The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

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https://collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_32ad424ed67248b39855a6f6ea030e5f

The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

Full title

The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

Publisher

England: Nature Publishing Group

Journal title

Nature communications, 2019, Vol.10 (1), p.4682-15

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_32ad424ed67248b39855a6f6ea030e5f

Language

English

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Publication information

Publisher

England: Nature Publishing Group

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SCOPE AND CONTENTS

Contents

A priority in cancer research is to innovate therapies that are not only effective against tumor progression but also address comorbidities such as cachexia that limit quality and quantity of life. We demonstrate that TLR7/8 agonist R848 induces anti-tumor responses and attenuates cachexia in murine models of pancreatic ductal adenocarcinoma (PDAC)...

ALTERNATIVE TITLES

Full title

The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer

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PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_32ad424ed67248b39855a6f6ea030e5f

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_32ad424ed67248b39855a6f6ea030e5f

OTHER IDENTIFIERS

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-019-12657-w

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