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Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

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Record title

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Record identifier

TN_cdi_doaj_primary_oai_doaj_org_article_a728a4a3f5614b2a9d19997422e58055

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

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https://collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a728a4a3f5614b2a9d19997422e58055

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Full title

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

Publisher

London: Nature Publishing Group

Journal title

Nature communications, 2021, Vol.12 (1), p.3362-3362

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_a728a4a3f5614b2a9d19997422e58055

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group

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SCOPE AND CONTENTS

Contents

Abstract
Diabetes can be caused by an insufficiency in β-cell mass. Here, we performed a genetic screen in a zebrafish model of β-cell loss to identify pathways promoting β-cell regeneration. We found that both folate receptor 1 (
folr1
) overexpression and treatment with folinic acid, stimulated β-cell differentiation in zebrafish. Treatm...

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Full title

Reinforcing one-carbon metabolism via folic acid/Folr1 promotes β-cell differentiation

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PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_a728a4a3f5614b2a9d19997422e58055

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_a728a4a3f5614b2a9d19997422e58055

OTHER IDENTIFIERS

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-021-23673-0

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