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Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

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Record title

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

Record identifier

TN_cdi_doaj_primary_oai_doaj_org_article_b91ffe9fd06f4dd8ae5b0aa7c12c5d8e

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

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https://collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b91ffe9fd06f4dd8ae5b0aa7c12c5d8e

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

Full title

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

Publisher

England: Nature Publishing Group

Journal title

Nature communications, 2019, Vol.10 (1), p.4451-15

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_b91ffe9fd06f4dd8ae5b0aa7c12c5d8e

Language

English

Formats

Publication information

Publisher

England: Nature Publishing Group

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SCOPE AND CONTENTS

Contents

TCR-gene-transfer is an efficient strategy to produce therapeutic T cells of defined antigen specificity. However, there are substantial variations in the cell surface expression levels of human TCRs, which can impair the function of engineered T cells. Here we demonstrate that substitutions of 3 amino acid residues in the framework of the TCR vari...

ALTERNATIVE TITLES

Full title

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function

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PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_b91ffe9fd06f4dd8ae5b0aa7c12c5d8e

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_b91ffe9fd06f4dd8ae5b0aa7c12c5d8e

OTHER IDENTIFIERS

ISSN

2041-1723

E-ISSN

2041-1723

DOI

10.1038/s41467-019-12441-w

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