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Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2- d ]pyrimidine non-nuc...

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Record title

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2- d ]pyrimidine non-nucleoside inhibitors

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TN_cdi_doaj_primary_oai_doaj_org_article_fd94ebe8a4794432ad4c0bae03908284

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2- d ]pyrimidine non-nucleoside inhibitors

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https://collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fd94ebe8a4794432ad4c0bae03908284

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2- d ]pyrimidine non-nucleoside inhibitors

Full title

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2- d ]pyrimidine non-nucleoside inhibitors

Publisher

England: eLife Sciences Publications, Ltd

Journal title

eLife, 2018, Vol.7 (2018)

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_fd94ebe8a4794432ad4c0bae03908284

Language

English

Formats

Publication information

Publisher

England: eLife Sciences Publications, Ltd

More information

SCOPE AND CONTENTS

Contents

Rapid generation of drug-resistant mutations in HIV-1 reverse transcriptase (RT), a prime target for anti-HIV therapy, poses a major impediment to effective anti-HIV treatment. Our previous efforts have led to the development of two novel non-nucleoside reverse transcriptase inhibitors (NNRTIs) with piperidine-substituted thiophene[3,2-
]pyrimid...

ALTERNATIVE TITLES

Full title

Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2- d ]pyrimidine non-nucleoside inhibitors

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PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_fd94ebe8a4794432ad4c0bae03908284

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_fd94ebe8a4794432ad4c0bae03908284

OTHER IDENTIFIERS

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.36340

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