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Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1

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TN_cdi_plos_journals_1771271804

Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1

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https://collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1771271804

Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1

Full title

Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1

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United States: Public Library of Science

Journal title

PloS one, 2016, Vol.11 (2), p.e0150232-e0150232

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TN_cdi_plos_journals_1771271804

Language

English

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Aminoimidazole Carboxamide - administration & dosage Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Antimetabolites, Antineoplastic - pharmacology Antineoplastic Combined Chemotherapy Protocols - pharmacology Biology Biology and Life Sciences Bone Neoplasms - pathology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Cancer cells Cancer therapies Cell cycle Cell Cycle - drug effects Cell division Cell Division - drug effects Cell Line, Tumor Cell proliferation Chemotherapy Combined treatment Complications and side effects Cytostatic Agents - administration & dosage Cytostatic Agents - pharmacology Data processing Dosage and administration Drug Screening Assays, Antitumor Drug Synergism Energy Metabolism - drug effects Enzyme Induction - drug effects Female Folic acid Forkhead Box Protein O1 Forkhead Transcription Factors - metabolism FOXO1 protein Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Glycolysis Glycolysis - drug effects Homeostasis Humans Kinases Lactates - metabolism MCF-7 Cells Medical prognosis Medicine Medicine and Health Sciences Membrane Potential, Mitochondrial - drug effects Metabolism Metabolites Methotrexate Methotrexate - administration & dosage Methotrexate - pharmacology Mitochondria Molecular Targeted Therapy Neoplasm Proteins - metabolism Osteosarcoma - pathology Oxidation Penicillin Pentose Pentose phosphate Pentose phosphate pathway Phosphates Physical Sciences Physiological aspects Protein kinases Protein turnover Ribonucleotides - administration & dosage Ribonucleotides - pharmacology RNA Interference Transcription factors Transcription Factors - antagonists & inhibitors Tumor cell lines

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TN_cdi_plos_journals_1771271804

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https://collection.sl.nsw.gov.au/record/TN_cdi_plos_journals_1771271804

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