SLNSW-Design, Synthesis, and In Vitro Evaluation of Hyd...-TN_cdi_proquest_journals_2365932016

Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

Full title: Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

Author/creator: Chaves, Sílvia, Resta, Simonetta, Rinaldo, Federica, Costa, Marina, Josselin, Romane, Gwizdala, Karolina, Piemontese, Luca, Capriati, Vito, Pereira-Santos, A Raquel, Cardoso, Sandra M, Santos, M Amélia.

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Record Identifier: TN_cdi_proquest_journals_2365932016

Language: English

Formats: Articles

Publishers: Switzerland: MDPI AG

Permalink: https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2365932016

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    Record title

    Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

    Record identifier

    TN_cdi_proquest_journals_2365932016

    Record permalink

    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2365932016

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    Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2365932016

    Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

    Full title

    Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

    Author / Creator

    Chaves, Sílvia ; Resta, Simonetta ; Rinaldo, Federica ; Costa, Marina ; Josselin, Romane ; Gwizdala, Karolina ; Piemontese, Luca ; Capriati, Vito ; Pereira-Santos, A Raquel ; Cardoso, Sandra M ; Santos, M Amélia

    Publisher

    Switzerland: MDPI AG

    Journal title

    Molecules (Basel, Switzerland), 2020, Vol.25 (4), p.985

    Record Identifier

    TN_cdi_proquest_journals_2365932016

    Language

    English

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    Articles

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    Acetylcholinesterase Acetylcholinesterase - chemistry Acetylcholinesterase - genetics Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Alzheimer Disease - pathology Alzheimer's disease Alzheimer´s disease Amyloid Amyloid beta-Peptides - antagonists & inhibitors anti-neurodegeneratives Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology Binding sites Bioavailability Biological activity Biological properties Chelates Chelating Agents - chemical synthesis Chelating Agents - chemistry Chelating Agents - pharmacology Chelation Cholinergics Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Copper Donepezil Donepezil - analogs & derivatives Donepezil - chemistry Donepezil - pharmacology Enzymes Fluorine Humans Hybrids hydroxyphenyl-benzimidazole Indazoles - chemistry Indazoles - pharmacology Isomerization Ligands Medical treatment metal chelation Metal ions Molecular Docking Simulation Molecular Structure multifunctional drugs Neuroblastoma Neuroblastoma cells Neurodegenerative diseases Neuroprotection Oxidative stress Pharmacokinetics Piperazine Piperazine - chemical synthesis Piperazine - chemistry Piperazine - pharmacology Piperidine Piperidines - chemical synthesis Piperidines - chemistry Piperidines - pharmacology Structure-Activity Relationship Toxicity Viability Zinc

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    TN_cdi_proquest_journals_2365932016

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2365932016

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