SLNSW-Synthesis, Biological Evaluation and In Silico St...-TN_cdi_proquest_journals_2397261870

Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors

Full title: Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors

Author/creator: Al-Warhi, Tarfah, El Kerdawy, Ahmed M, Aljaeed, Nada, Ismael, Omnia E, Ayyad, Rezk R, Eldehna, Wagdy M, Abdel-Aziz, Hatem A, Al-Ansary, Ghada H.

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Record Identifier: TN_cdi_proquest_journals_2397261870

Language: English

Formats: Articles

Publishers: Switzerland: MDPI AG

Permalink: https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2397261870

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    Record title

    Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors

    Record identifier

    TN_cdi_proquest_journals_2397261870

    Record permalink

    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2397261870

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    Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2397261870

    Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors

    Full title

    Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors

    Author / Creator

    Al-Warhi, Tarfah ; El Kerdawy, Ahmed M ; Aljaeed, Nada ; Ismael, Omnia E ; Ayyad, Rezk R ; Eldehna, Wagdy M ; Abdel-Aziz, Hatem A ; Al-Ansary, Ghada H

    Publisher

    Switzerland: MDPI AG

    Journal title

    Molecules (Basel, Switzerland), 2020, Vol.25 (9), p.2031

    Record Identifier

    TN_cdi_proquest_journals_2397261870

    Language

    English

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    Acids Amino acids anti-proliferative activity Anticancer properties Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology Antitumor agents Apoptosis Apoptosis - drug effects Binding Sites Biotechnology Breast cancer Breast Neoplasms - drug therapy Cancer therapies CDK4 inhibitors Cell cycle Cell Cycle Checkpoints - drug effects Cell Proliferation - drug effects Computer Simulation Conjugates Cyclin-dependent kinase Cyclin-dependent kinase 4 Cyclin-Dependent Kinase 4 - antagonists & inhibitors Cyclin-Dependent Kinase 4 - chemistry Cyclin-dependent kinases Cytotoxicity Drug Design Drug Screening Assays, Antitumor FDA approval Female Humans Hybrids Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Hydrophobicity Indoles Indoles - chemistry Indoles - pharmacology Inhibitors Inhibitory Concentration 50 Kinases Malignancy MCF-7 Cells Molecular docking Molecular Docking Simulation Molecular Structure Nuclei (cytology) Optimization oxindole Oxindoles - chemistry Oxindoles - pharmacology Protein Kinase Inhibitors - chemical synthesis Protein Kinase Inhibitors - pharmacology Structure-Activity Relationship Tetralin

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    TN_cdi_proquest_journals_2397261870

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2397261870

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