SLNSW-BL-8040, a CXCR4 antagonist, in combination with ...-TN_cdi_proquest_journals_2414579499

BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial

Full title: BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial

Author/creator: Bockorny, Bruno, Semenisty, Valerya, Macarulla, Teresa, Borazanci, Erkut, Wolpin, Brian M, Stemmer, Salomon M, Golan, Talia, Geva, Ravit, Borad, Mitesh J, Pedersen, Katrina S, Park, Joon Oh, Ramirez, Robert A, Abad, David G, Feliu, Jaime, Muñoz, Andres, Ponz-Sarvise, Mariano, Peled, Amnon, Lustig, Tzipora M, Bohana-Kashtan, Osnat, Shaw, Stephen M, Sorani, Ella, Chaney, Marya, Kadosh, Shaul, Vainstein Haras, Abi, Von Hoff, Daniel D, Hidalgo, Manuel.

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Record Identifier: TN_cdi_proquest_journals_2414579499

Language: English

Formats: Articles

Publishers: United States: Nature Publishing Group

Permalink: https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2414579499

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    BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial

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    TN_cdi_proquest_journals_2414579499

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2414579499

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    BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2414579499

    BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial

    Full title

    BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial

    Author / Creator

    Bockorny, Bruno ; Semenisty, Valerya ; Macarulla, Teresa ; Borazanci, Erkut ; Wolpin, Brian M ; Stemmer, Salomon M ; Golan, Talia ; Geva, Ravit ; Borad, Mitesh J ; Pedersen, Katrina S ; Park, Joon Oh ; Ramirez, Robert A ; Abad, David G ; Feliu, Jaime ; Muñoz, Andres ; Ponz-Sarvise, Mariano ; Peled, Amnon ; Lustig, Tzipora M ; Bohana-Kashtan, Osnat ; Shaw, Stephen M ; Sorani, Ella ; Chaney, Marya ; Kadosh, Shaul ; Vainstein Haras, Abi ; Von Hoff, Daniel D ; Hidalgo, Manuel

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    United States: Nature Publishing Group

    Journal title

    Nature medicine, 2020, Vol.26 (6), p.878-885

    Record Identifier

    TN_cdi_proquest_journals_2414579499

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    English

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    Adenocarcinoma Aged Aged, 80 and over Animal models Antagonists (Biochemistry) Antibodies, Monoclonal, Humanized - administration & dosage Antineoplastic Agents, Immunological Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Cancer Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - pathology Carcinoma, Pancreatic Ductal - secondary CD8 antigen CD8-Positive T-Lymphocytes - pathology Cell death Cell survival Chemokine receptors Chemokines Chemotherapy Clinical trials CXCR4 protein Disease control Drug therapy Drug therapy, Combination Female Fluorouracil - administration & dosage Health aspects Humans Immunoregulation Immunosuppressive agents Immunotherapy Infiltration Irinotecan - administration & dosage Leucovorin - administration & dosage Liver Neoplasms - drug therapy Liver Neoplasms - secondary Lung Neoplasms - drug therapy Lung Neoplasms - secondary Lymph Nodes - pathology Lymphatic Metastasis Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - pathology Male Metastases Metastasis Middle Aged Monoclonal antibodies Myeloid-Derived Suppressor Cells - pathology Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology PD-1 protein Pembrolizumab Peptides - administration & dosage Peritoneal Neoplasms - drug therapy Peritoneal Neoplasms - secondary Receptors, CXCR4 - antagonists & inhibitors Retroperitoneal Neoplasms - drug therapy Retroperitoneal Neoplasms - secondary Safety Suppressor cells Survival Rate T-Lymphocytes, Regulatory - pathology Targeted cancer therapy Testing Treatment Outcome

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