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Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

Full title: Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

Author/creator: Qi, Xiaofeng, Friedberg, Lucas, De Bose-Boyd, Ryan, Long, Tao, Li, Xiaochun.

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Record Identifier: TN_cdi_proquest_journals_2471566771

Language: English

Formats: Articles

Publishers: United States: Nature Publishing Group

Permalink: https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2471566771

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    Record title

    Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

    Record identifier

    TN_cdi_proquest_journals_2471566771

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2471566771

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    Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

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    Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

    Full title

    Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling

    Author / Creator

    Qi, Xiaofeng ; Friedberg, Lucas ; De Bose-Boyd, Ryan ; Long, Tao ; Li, Xiaochun

    Publisher

    United States: Nature Publishing Group

    Journal title

    Nature chemical biology, 2020, Vol.16 (12), p.1368-1375

    Record Identifier

    TN_cdi_proquest_journals_2471566771

    Language

    English

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    Articles

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    Amino Acid Sequence Amino Acid Substitution Binding Sites Cell membranes Cholesterol - analogs & derivatives Cholesterol - chemistry Cholesterol - metabolism Cyclohexylamines - chemistry Cyclohexylamines - pharmacology Frizzled protein G protein-coupled receptors Gene Expression Regulation GTP-Binding Protein alpha Subunits - chemistry GTP-Binding Protein alpha Subunits - genetics GTP-Binding Protein alpha Subunits - metabolism GTP-Binding Protein beta Subunits - chemistry GTP-Binding Protein beta Subunits - genetics GTP-Binding Protein beta Subunits - metabolism GTP-Binding Protein gamma Subunits - chemistry GTP-Binding Protein gamma Subunits - genetics GTP-Binding Protein gamma Subunits - metabolism Hedgehog protein HEK293 Cells Helices Humans Molecular Docking Simulation Occupancy Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid Signal Transduction Signaling Single-Chain Antibodies Smoothened Receptor - agonists Smoothened Receptor - chemistry Smoothened Receptor - genetics Smoothened Receptor - metabolism Sterols Thiophenes - chemistry Thiophenes - pharmacology

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    TN_cdi_proquest_journals_2471566771

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2471566771

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