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APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids

Full title: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids

Author/creator: Zhao, Jing, Fu, Yuan, Yamazaki, Yu, Ren, Yingxue, Davis, Mary D, Liu, Chia-Chen, Lu, Wenyan, Wang, Xue, Chen, Kai, Cherukuri, Yesesri, Jia, Lin, Martens, Yuka A, Job, Lucy, Shue, Francis, Nguyen, Thanh Thanh, Younkin, Steven G, Graff-Radford, Neill R, Wszolek, Zbigniew K, Brafman, David A, Asmann, Yan W, Ertekin-Taner, Nilüfer, Kanekiyo, Takahisa, Bu, Guojun.

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Record Identifier: TN_cdi_proquest_journals_2522237027

Language: English

Formats: Articles

Publishers: England: Nature Publishing Group

Permalink: https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2522237027

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    Record title

    APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids

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    TN_cdi_proquest_journals_2522237027

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2522237027

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    APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2522237027

    APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids

    Full title

    APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids

    Author / Creator

    Zhao, Jing ; Fu, Yuan ; Yamazaki, Yu ; Ren, Yingxue ; Davis, Mary D ; Liu, Chia-Chen ; Lu, Wenyan ; Wang, Xue ; Chen, Kai ; Cherukuri, Yesesri ; Jia, Lin ; Martens, Yuka A ; Job, Lucy ; Shue, Francis ; Nguyen, Thanh Thanh ; Younkin, Steven G ; Graff-Radford, Neill R ; Wszolek, Zbigniew K ; Brafman, David A ; Asmann, Yan W ; Ertekin-Taner, Nilüfer ; Kanekiyo, Takahisa ; Bu, Guojun

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    England: Nature Publishing Group

    Journal title

    Nature communications, 2020, Vol.11 (1), p.5540-5540

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    TN_cdi_proquest_journals_2522237027

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    English

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    Articles

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    Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Alzheimers disease Apolipoprotein E Apolipoprotein E3 - genetics Apolipoprotein E3 - metabolism Apolipoprotein E4 Apolipoprotein E4 - genetics Apoptosis Cognition Conversion Dementia disorders Gene Expression Regulation Gene sequencing Genotype Genotypes Humans Induced Pluripotent Stem Cells - metabolism Inhibitory postsynaptic potentials Mechanisms of disease Metabolism Neurodegeneration Neurodegenerative diseases Organoids Organoids - metabolism Organoids - pathology Pathogenesis Patients Phenotypes Pluripotency Ribonucleic acid Risk analysis Risk factors RNA RNA - metabolism Stem cells Synapses - metabolism Tau protein Transcriptome Transcriptomics

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    TN_cdi_proquest_journals_2522237027

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2522237027

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