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First‐in‐human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN‐101, a dual CD28/ICOS antagonist, in healthy adult subjects

Full title: First‐in‐human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN‐101, a dual CD28/ICOS antagonist, in healthy adult subjects

Author/creator: Yang, Jing, Lickliter, Jason D., Hillson, Jan L., Means, Gary D., Sanderson, Russell J., Carley, Kay, Tercero, Almudena, Manjarrez, Kristi L., Wiley, Jennifer R., Peng, Stanford L..

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Record Identifier: TN_cdi_proquest_journals_2554373219

Language: English

Formats: Articles

Publishers: United States: John Wiley & Sons, Inc

Permalink: https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2554373219

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    Record title

    First‐in‐human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN‐101, a dual CD28/ICOS antagonist, in healthy adult subjects

    Record identifier

    TN_cdi_proquest_journals_2554373219

    Record permalink

    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2554373219

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    First‐in‐human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN‐101, a dual CD28/ICOS antagonist, in healthy adult subjects

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2554373219

    First‐in‐human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN‐101, a dual CD28/ICOS antagonist, in healthy adult subjects

    Full title

    First‐in‐human study of the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALPN‐101, a dual CD28/ICOS antagonist, in healthy adult subjects

    Author / Creator

    Yang, Jing ; Lickliter, Jason D. ; Hillson, Jan L. ; Means, Gary D. ; Sanderson, Russell J. ; Carley, Kay ; Tercero, Almudena ; Manjarrez, Kristi L. ; Wiley, Jennifer R. ; Peng, Stanford L.

    Publisher

    United States: John Wiley & Sons, Inc

    Journal title

    Clinical and translational science, 2021, Vol.14 (4), p.1314-1326

    Record Identifier

    TN_cdi_proquest_journals_2554373219

    Language

    English

    Formats

    Articles

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    Subjects and topics

    Administration, Intravenous Adolescent Adult Adverse events Aged Antibodies Arthritis Autoimmune diseases Bioavailability CD28 antigen CD28 Antigens - antagonists & inhibitors CD28 Antigens - metabolism Cytokines Dosage Enterotoxin B Fc receptors Female Flow cytometry Fusion protein Graft versus host disease Healthy Volunteers Humans Immunization Immunoassay Immunogenicity Immunoglobulins Immunomodulation Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - adverse effects Immunosuppressive Agents - pharmacokinetics Inducible T-Cell Co-Stimulator Protein - antagonists & inhibitors Inducible T-Cell Co-Stimulator Protein - metabolism Inflammatory bowel disease Inflammatory diseases Intravenous administration Laboratories Ligands Lupus Lymphocytes Lymphocytes T Male Middle Aged Pharmacodynamics Pharmacokinetics Safety and security measures Staphylococcal enterotoxin B T cells Viral antibodies Young Adult

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    Record Identifier

    TN_cdi_proquest_journals_2554373219

    Permalink

    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2554373219

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