SLNSW-Trivalent PROTACs enhance protein degradation via...-TN_cdi_proquest_journals_2613071439

Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Full title: Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Author/creator: Imaide, Satomi, Riching, Kristin M, Makukhin, Nikolai, Vetma, Vesna, Whitworth, Claire, Hughes, Scott J, Trainor, Nicole, Mahan, Sarah D, Murphy, Nancy, Cowan, Angus D, Chan, Kwok-Ho, Craigon, Conner, Testa, Andrea, Maniaci, Chiara, Urh, Marjeta, Daniels, Danette L, Ciulli, Alessio.

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Record Identifier: TN_cdi_proquest_journals_2613071439

Language: English

Formats: Articles

Publishers: United States: Nature Publishing Group

Permalink: https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2613071439

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    Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

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    TN_cdi_proquest_journals_2613071439

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2613071439

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    Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

    Full title

    Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

    Author / Creator

    Imaide, Satomi ; Riching, Kristin M ; Makukhin, Nikolai ; Vetma, Vesna ; Whitworth, Claire ; Hughes, Scott J ; Trainor, Nicole ; Mahan, Sarah D ; Murphy, Nancy ; Cowan, Angus D ; Chan, Kwok-Ho ; Craigon, Conner ; Testa, Andrea ; Maniaci, Chiara ; Urh, Marjeta ; Daniels, Danette L ; Ciulli, Alessio

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    United States: Nature Publishing Group

    Journal title

    Nature chemical biology, 2021, Vol.17 (11), p.1157-1167

    Record Identifier

    TN_cdi_proquest_journals_2613071439

    Language

    English

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    Articles

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    Anticancer properties Antitumor activity Avidity Binding Biodegradation Chimeras Cooperativity Degradation Humans Pharmacokinetics Proteins Proteolysis Ubiquitin-protein ligase Ubiquitin-Protein Ligases - metabolism Valency VHL protein

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    TN_cdi_proquest_journals_2613071439

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    https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_journals_2613071439

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