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Cross―neutralization of influenza A viruses mediated by a single antibody loop

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Cross―neutralization of influenza A viruses mediated by a single antibody loop

Record identifier

TN_cdi_proquest_miscellaneous_1081436660

Cross―neutralization of influenza A viruses mediated by a single antibody loop

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https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1081436660

Cross―neutralization of influenza A viruses mediated by a single antibody loop

Full title

Cross―neutralization of influenza A viruses mediated by a single antibody loop

Publisher

London: Nature Publishing Group

Journal title

Nature (London), 2012, Vol.489 (7417), p.526-532

Record Identifier

TN_cdi_proquest_miscellaneous_1081436660

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group

Subjects

Subjects and topics

Agglutinins Animals Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - genetics Antibodies, Neutralizing - immunology Antibodies, Viral - chemistry Antibodies, Viral - genetics Antibodies, Viral - immunology Antibody Specificity - genetics Antibody Specificity - immunology Antigens, Viral - chemistry Antigens, Viral - immunology Applied microbiology Binding Sites Biological and medical sciences Complementarity Determining Regions - chemistry Complementarity Determining Regions - genetics Complementarity Determining Regions - immunology Complementarity-determining regions Conserved Sequence Cross Reactions - genetics Cross Reactions - immunology Crystallography, X-Ray Enzyme-Linked Immunosorbent Assay Epitopes - chemistry Epitopes - immunology Fundamental and applied biological sciences. Psychology Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - immunology Inactivation Infections Influenza A virus - chemistry Influenza A virus - classification Influenza A virus - immunology Influenza A Virus, H1N1 Subtype - chemistry Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H3N2 Subtype - chemistry Influenza A Virus, H3N2 Subtype - immunology Influenza Vaccines - immunology Influenza viruses Mice Microbiology Models, Molecular Molecular Sequence Data Mutation - genetics Observations Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Protein Conformation Proteins Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viruses

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SCOPE AND CONTENTS

Contents

Immune recognition of protein antigens relies on the combined interaction of multiple antibody loops, which provide a fairly large footprint and constrain the size and shape of protein surfaces that can be targeted. Single protein loops can mediate extremely high-affinity binding, but it is unclear whether such a mechanism is available to antibodie...

ALTERNATIVE TITLES

Full title

Cross―neutralization of influenza A viruses mediated by a single antibody loop

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PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_proquest_miscellaneous_1081436660

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1081436660

OTHER IDENTIFIERS

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature11414

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