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Stepwise Unfolding of Ankyrin Repeats in a Single Protein Revealed by Atomic Force Microscopy

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Record title

Stepwise Unfolding of Ankyrin Repeats in a Single Protein Revealed by Atomic Force Microscopy

Record identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1367297

Stepwise Unfolding of Ankyrin Repeats in a Single Protein Revealed by Atomic Force Microscopy

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https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1367297

Stepwise Unfolding of Ankyrin Repeats in a Single Protein Revealed by Atomic Force Microscopy

Full title

Stepwise Unfolding of Ankyrin Repeats in a Single Protein Revealed by Atomic Force Microscopy

Publisher

United States: Elsevier Inc

Journal title

Biophysical journal, 2006, Vol.90 (4), p.L30-L32

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1367297

Language

English

Formats

Publication information

Publisher

United States: Elsevier Inc

More information

SCOPE AND CONTENTS

Contents

Using single-molecule atomic force microscopy, we find that a protein consisting of six identical ankyrin repeat units flanked by N- and C-terminal modules (N6C) unfolds in a stepwise, unit-by-unit fashion under a mechanical force. Stretching a N6C molecule results in a sawtooth pattern fingerprint, with as many as six peaks separated by ∼10
nm...

ALTERNATIVE TITLES

Full title

Stepwise Unfolding of Ankyrin Repeats in a Single Protein Revealed by Atomic Force Microscopy

AUTHORS, ARTISTS AND CONTRIBUTORS

Identifiers

PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1367297

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1367297

OTHER IDENTIFIERS

ISSN

0006-3495

E-ISSN

1542-0086

DOI

10.1529/biophysj.105.078436

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