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Introduction of Exogenous T-cell Receptors Into Human Hematopoietic Progenitors Results in Exclusion...

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Introduction of Exogenous T-cell Receptors Into Human Hematopoietic Progenitors Results in Exclusion of Endogenous T-cell Receptor Expression

Record identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3666627

Introduction of Exogenous T-cell Receptors Into Human Hematopoietic Progenitors Results in Exclusion of Endogenous T-cell Receptor Expression

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https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3666627

Introduction of Exogenous T-cell Receptors Into Human Hematopoietic Progenitors Results in Exclusion of Endogenous T-cell Receptor Expression

Full title

Introduction of Exogenous T-cell Receptors Into Human Hematopoietic Progenitors Results in Exclusion of Endogenous T-cell Receptor Expression

Publisher

United States: Elsevier Inc

Journal title

Molecular therapy, 2013, Vol.21 (5), p.1055-1063

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3666627

Language

English

Formats

Publication information

Publisher

United States: Elsevier Inc

More information

SCOPE AND CONTENTS

Contents

Current tumor immunotherapy approaches include the genetic modification of peripheral T cells to express tumor antigen-specific T-cell receptors (TCRs). The approach, tested in melanoma, has led to some limited success of tumor regression in patients. Yet, the introduction of exogenous TCRs into mature T cells entails an underlying risk; the genera...

ALTERNATIVE TITLES

Full title

Introduction of Exogenous T-cell Receptors Into Human Hematopoietic Progenitors Results in Exclusion of Endogenous T-cell Receptor Expression

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PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3666627

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3666627

OTHER IDENTIFIERS

ISSN

1525-0016

E-ISSN

1525-0024

DOI

10.1038/mt.2013.28

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