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Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

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Record title

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

Record identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3720791

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

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https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3720791

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

Full title

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

Publisher

United States: Nature Publishing Group

Journal title

Nature chemical biology, 2013, Vol.9 (8), p.499-506

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3720791

Language

English

Formats

Publication information

Publisher

United States: Nature Publishing Group

More information

SCOPE AND CONTENTS

Contents

We report a new class of thiophene (TP) compounds that kill Mycobacterium tuberculosis by the previously uncharacterized mechanism of Pks13 inhibition. An F79S mutation near the catalytic Ser55 site in Pks13 conferred TP resistance in M. tuberculosis. Overexpression of wild-type Pks13 resulted in TP resistance, and overexpression of the Pks13(F79S)...

ALTERNATIVE TITLES

Full title

Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis

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PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3720791

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3720791

OTHER IDENTIFIERS

ISSN

1552-4450

E-ISSN

1552-4469

DOI

10.1038/nchembio.1277

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