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Evolution of thermophilic DNA polymerases for the recognition and amplification of C2'-modified DNA

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Evolution of thermophilic DNA polymerases for the recognition and amplification of C2'-modified DNA

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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4880425

Evolution of thermophilic DNA polymerases for the recognition and amplification of C2'-modified DNA

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https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4880425

Evolution of thermophilic DNA polymerases for the recognition and amplification of C2'-modified DNA

Full title

Evolution of thermophilic DNA polymerases for the recognition and amplification of C2'-modified DNA

Publisher

England: Nature Publishing Group

Journal title

Nature chemistry, 2016, Vol.8 (6), p.556-562

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4880425

Language

English

Formats

Publication information

Publisher

England: Nature Publishing Group

More information

SCOPE AND CONTENTS

Contents

The PCR amplification of oligonucleotides enables the evolution of sequences called aptamers that bind specific targets with antibody-like affinity. However, in many applications the use of these aptamers is limited by nuclease-mediated degradation. In contrast, oligonucleotides that are modified at their sugar C2' positions with methoxy or fluorin...

ALTERNATIVE TITLES

Full title

Evolution of thermophilic DNA polymerases for the recognition and amplification of C2'-modified DNA

Identifiers

PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4880425

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4880425

OTHER IDENTIFIERS

ISSN

1755-4330

E-ISSN

1755-4349

DOI

10.1038/nchem.2493

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