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Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-thro...

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Record title

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing

Record identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4895203

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing

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https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4895203

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing

Full title

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing

Publisher

England: Nature Publishing Group

Journal title

Nature protocols, 2016, Vol.11 (5), p.853-871

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4895203

Language

English

Formats

Publication information

Publisher

England: Nature Publishing Group

More information

SCOPE AND CONTENTS

Contents

Unbiased, high-throughput assays for detecting and quantifying DNA double-stranded breaks (DSBs) across the genome in mammalian cells will facilitate basic studies of the mechanisms that generate and repair endogenous DSBs. They will also enable more applied studies, such as those to evaluate the on- and off-target activities of engineered nuclease...

ALTERNATIVE TITLES

Full title

Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing

Identifiers

PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4895203

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4895203

OTHER IDENTIFIERS

ISSN

1754-2189

E-ISSN

1750-2799

DOI

10.1038/nprot.2016.043

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