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Structure-based discovery of opioid analgesics with reduced side effects

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Record title

Structure-based discovery of opioid analgesics with reduced side effects

Record identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5161585

Structure-based discovery of opioid analgesics with reduced side effects

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https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5161585

Structure-based discovery of opioid analgesics with reduced side effects

Full title

Structure-based discovery of opioid analgesics with reduced side effects

Publisher

England: Nature Publishing Group

Journal title

Nature (London), 2016, Vol.537 (7619), p.185-190

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5161585

Language

English

Formats

Publication information

Publisher

England: Nature Publishing Group

More information

SCOPE AND CONTENTS

Contents

Morphine is an alkaloid from the opium poppy used to treat pain. The potentially lethal side effects of morphine and related opioids-which include fatal respiratory depression-are thought to be mediated by μ-opioid-receptor (μOR) signalling through the β-arrestin pathway or by actions at other receptors. Conversely, G-protein μOR signalling is thou...

ALTERNATIVE TITLES

Full title

Structure-based discovery of opioid analgesics with reduced side effects

Identifiers

PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5161585

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5161585

OTHER IDENTIFIERS

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature19112

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