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Plasticity in binding confers selectivity in ligand-induced protein degradation

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Record title

Plasticity in binding confers selectivity in ligand-induced protein degradation

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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6202246

Plasticity in binding confers selectivity in ligand-induced protein degradation

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Plasticity in binding confers selectivity in ligand-induced protein degradation

Full title

Plasticity in binding confers selectivity in ligand-induced protein degradation

Publisher

United States: Nature Publishing Group

Journal title

Nature chemical biology, 2018, Vol.14 (7), p.706-714

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6202246

Language

English

Formats

Publication information

Publisher

United States: Nature Publishing Group

More information

SCOPE AND CONTENTS

Contents

Heterobifunctional small-molecule degraders that induce protein degradation through ligase-mediated ubiquitination have shown considerable promise as a new pharmacological modality. However, we currently lack a detailed understanding of the molecular basis for target recruitment and selectivity, which is critically required to enable rational desig...

ALTERNATIVE TITLES

Full title

Plasticity in binding confers selectivity in ligand-induced protein degradation

Identifiers

PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6202246

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6202246

OTHER IDENTIFIERS

ISSN

1552-4450

E-ISSN

1552-4469

DOI

10.1038/s41589-018-0055-y

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