SLNSW-Blocking IL-1β reverses the immunosuppression in ...-TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6347724

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

Full title: Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

Author/creator: Kaplanov, Irena, Carmi, Yaron, Kornetsky, Rachel, Shemesh, Avishai, Shurin, Galina V., Shurin, Michael R., Dinarello, Charles A., Voronov, Elena, Apte, Ron N..

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Record Identifier: TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6347724

Language: English

Formats: Articles

Publishers: United States: National Academy of Sciences

Permalink: https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6347724

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    Record title

    Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

    Record identifier

    TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6347724

    Record permalink

    https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6347724

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    Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

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    https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6347724

    Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

    Full title

    Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

    Author / Creator

    Kaplanov, Irena ; Carmi, Yaron ; Kornetsky, Rachel ; Shemesh, Avishai ; Shurin, Galina V. ; Shurin, Michael R. ; Dinarello, Charles A. ; Voronov, Elena ; Apte, Ron N.

    Publisher

    United States: National Academy of Sciences

    Journal title

    Proceedings of the National Academy of Sciences - PNAS, 2019, Vol.116 (4), p.1361-1369

    Record Identifier

    TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6347724

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    English

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    Articles

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    Animals Antibodies, Monoclonal - pharmacology Anticancer properties Antineoplastic Agents - pharmacology antitumor immunity anti–PD-1 Biological Sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cancer CD11b antigen CD11b Antigen - metabolism CD8 antigen CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - metabolism Cell Differentiation - drug effects Cell Line, Tumor Chemokines Colony-stimulating factor Colony-Stimulating Factors - metabolism Dendritic cells Dendritic Cells - drug effects Dendritic Cells - metabolism Differentiation Female Granzyme B Granzymes - pharmacology Humans IL-1β Immunity Immunosuppression Immunosuppression - methods Immunotherapy Inflammation Inflammation - metabolism Inhibition Interferon-gamma - metabolism Interleukin Interleukin 10 Interleukin 12 Interleukin-1beta - antagonists & inhibitors Lymphocytes Lymphocytes B Macrophage colony-stimulating factor Macrophages Macrophages - drug effects Macrophages - metabolism Medical immunity Metastases Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Monocyte chemoattractant protein 1 Monocytes Monocytes - drug effects Monocytes - metabolism PD-1 protein PNAS Plus Programmed Cell Death 1 Receptor - antagonists & inhibitors Recruitment SEE COMMENTARY Tumor Microenvironment - drug effects Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α Tumors γ-Interferon

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    TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6347724

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    https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6347724

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