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A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma

Record identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6440937

A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma

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https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6440937

A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma

Full title

A phase 1 trial of SGN-CD70A in patients with CD70-positive diffuse large B cell lymphoma and mantle cell lymphoma

Publisher

New York: Springer US

Journal title

Investigational new drugs, 2019, Vol.37 (2), p.297-306

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6440937

Language

English

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Adult Aged Aged, 80 and over Anemia Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal - therapeutic use Antibody-drug conjugate Anticancer properties Antimitotic agents Antineoplastic agents Antitumor activity B-cell lymphoma Benzodiazepines - chemistry Biomarkers, Tumor - metabolism CD27 Ligand - antagonists & inhibitors CD27 Ligand - immunology CD27 Ligand - metabolism CD70 antigen Complications and side effects Diffuse, large B cell, lymphoma (DLBCL) Dimers Dosage and administration Drug dosages Drug Resistance, Neoplasm - drug effects Drug therapy Exposure Fatigue Female Follow-Up Studies Gene Expression Regulation, Neoplastic - drug effects Genetic aspects Grade 3 follicular lymphoma Humans Immunoconjugates - pharmacokinetics Immunoconjugates - therapeutic use Lymphocytes B Lymphoma Lymphoma, B-Cell - drug therapy Lymphoma, B-Cell - immunology Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - pathology Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - immunology Lymphoma, Large B-Cell, Diffuse - metabolism Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Mantle-Cell - drug therapy Lymphoma, Mantle-Cell - immunology Lymphoma, Mantle-Cell - metabolism Lymphoma, Mantle-Cell - pathology Male Mantle Mantle cell lymphoma Maximum Tolerated Dose Medicine Medicine & Public Health Membrane proteins Middle Aged Nausea Neoplasm Recurrence, Local - drug therapy Neoplasm Recurrence, Local - immunology Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - pathology Non-Hodgkin's lymphomas Oncology Patients Pharmacology/Toxicology Phase I Studies Prognosis Proteins Pyrroles - chemistry Pyrrolobenzodiazepine dimer (PBD) Remission Salvage Therapy Studies Thrombocytopenia Tissue Distribution

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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6440937

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https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6440937

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