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Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib a...

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Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial

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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7513622

Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial

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https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7513622

Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial

Full title

Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial

Publisher

England: Elsevier Ltd

Journal title

The lancet oncology, 2015, Vol.16 (8), p.937-948

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7513622

Language

English

Formats

Publication information

Publisher

England: Elsevier Ltd

Subjects

Subjects and topics

Adenocarcinoma - blood Adenocarcinoma - drug therapy Adenocarcinoma - genetics Adenocarcinoma - mortality Adenocarcinoma - secondary Aged Antineoplastic Agents - therapeutic use Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Cancer patients Cancer therapies Class I Phosphatidylinositol 3-Kinases Clinical Trials, Phase III as Topic Colorectal cancer Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Deoxyribonucleic acid Disease Progression Disease-Free Survival DNA DNA Mutational Analysis DNA, Neoplasm - blood DNA, Neoplasm - genetics Drug resistance Female Genetic Predisposition to Disease Genetic research Genetic testing Genotype & phenotype Hematology, Oncology and Palliative Medicine Human health and pathology Humans Kaplan-Meier Estimate Life Sciences Liver Male Medical colleges Medical prognosis Medical research Medicine, Experimental Metastasis Middle Aged Mutation Patient Selection Patients Phenotype Phenylurea Compounds - therapeutic use Phosphatidylinositol 3-Kinases - blood Phosphatidylinositol 3-Kinases - genetics Plasma Precision Medicine Predictive Value of Tests Prognosis Proportional Hazards Models Proteins Proto-Oncogene Proteins - blood Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - blood Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) Pyridines - therapeutic use Randomized Controlled Trials as Topic ras Proteins - blood ras Proteins - genetics Real-Time Polymerase Chain Reaction Receptor, TIE-1 - blood Retrospective Studies Studies Time Factors Treatment Outcome Tumors

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SCOPE AND CONTENTS

Contents

Summary Background Tumour mutational status is an important determinant of the response of metastatic colorectal cancer to targeted treatments. However, the genotype of the tissue obtained at the time of diagnosis might not accurately represent tumour genotype after multiple lines of treatment. This retrospective exploratory analysis investigated t...

ALTERNATIVE TITLES

Full title

Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial

Identifiers

PRIMARY IDENTIFIERS

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7513622

Permalink

https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7513622

OTHER IDENTIFIERS

ISSN

1470-2045

E-ISSN

1474-5488

DOI

10.1016/S1470-2045(15)00138-2

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