SLNSW-Phase I First-in-Human Dose Escalation Study of t...-TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8632688

Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms

Full title: Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms

Author/creator: Steensma, David P, Wermke, Martin, Klimek, Virginia M, Greenberg, Peter L, Font, Patricia, Komrokji, Rami S, Yang, Jay, Brunner, Andrew M, Carraway, Hetty E, Ades, Lionel, Al-Kali, Aref, Alonso-Dominguez, Juan M, Alfonso-Piérola, Ana, Coombs, Catherine C, Deeg, H Joachim, Flinn, Ian, Foran, James M, Garcia-Manero, Guillermo, Maris, Michael B, McMasters, Malgorzata, Micol, Jean-Baptiste, De Oteyza, Jaime Perez, Thol, Felicitas, Wang, Eunice S, Watts, Justin M, Taylor, Justin, Stone, Richard, Gourineni, Vikram, Marino, Alyssa J, Yao, Huilan, Destenaves, Benoit, Yuan, Xiaobin, Yu, Kun, Dar, Sara, Ohanjanian, Lernik, Kuida, Keisuke, Xiao, Jianjun, Scholz, Catherine, Gualberto, Antonio, Platzbecker, Uwe.

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Record Identifier: TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8632688

Language: English

Formats: Articles

Publishers: England: Nature Publishing Group

Permalink: https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8632688

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    Record title

    Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms

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    TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8632688

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    https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8632688

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    Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms

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    https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8632688

    Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms

    Full title

    Phase I First-in-Human Dose Escalation Study of the oral SF3B1 modulator H3B-8800 in myeloid neoplasms

    Author / Creator

    Steensma, David P ; Wermke, Martin ; Klimek, Virginia M ; Greenberg, Peter L ; Font, Patricia ; Komrokji, Rami S ; Yang, Jay ; Brunner, Andrew M ; Carraway, Hetty E ; Ades, Lionel ; Al-Kali, Aref ; Alonso-Dominguez, Juan M ; Alfonso-Piérola, Ana ; Coombs, Catherine C ; Deeg, H Joachim ; Flinn, Ian ; Foran, James M ; Garcia-Manero, Guillermo ; Maris, Michael B ; McMasters, Malgorzata ; Micol, Jean-Baptiste ; De Oteyza, Jaime Perez ; Thol, Felicitas ; Wang, Eunice S ; Watts, Justin M ; Taylor, Justin ; Stone, Richard ; Gourineni, Vikram ; Marino, Alyssa J ; Yao, Huilan ; Destenaves, Benoit ; Yuan, Xiaobin ; Yu, Kun ; Dar, Sara ; Ohanjanian, Lernik ; Kuida, Keisuke ; Xiao, Jianjun ; Scholz, Catherine ; Gualberto, Antonio ; Platzbecker, Uwe

    Publisher

    England: Nature Publishing Group

    Journal title

    Leukemia, 2021, Vol.35 (12), p.3542-3550

    Record Identifier

    TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8632688

    Language

    English

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    Subjects and topics

    Administration, Oral Adverse events Aged Aged, 80 and over Biomarkers Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Blood transfusion Cancer Chronic myelomonocytic leukemia Clinical trials Creatinine Diarrhea Dosage Dose-response relationship (Biochemistry) Dose-Response Relationship, Drug Drug development Drug dosages Drug therapy Erythrocytes Female Gene mutations Genetic aspects Health aspects Health sciences Humans Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Male Medical research Middle Aged Mitochondria Mutation Mutation, Missense Myelocytic leukemia Myelodysplastic Syndromes - drug therapy Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - metabolism Myelodysplastic Syndromes - pathology Nausea Neoplasms Nonlymphoid leukemia Patient Safety Patients Phosphoproteins - antagonists & inhibitors Phosphoproteins - genetics Phosphoproteins - metabolism Piperazines - adverse effects Piperazines - therapeutic use Porphyrins Pyridines - adverse effects Pyridines - therapeutic use Red blood cells RNA Splicing Factors - antagonists & inhibitors RNA Splicing Factors - genetics RNA Splicing Factors - metabolism Schedules Splicing Splicing factors Transfusion Treatment Outcome Tumors Vomiting

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    TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8632688

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    https://collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8632688

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